合肥综合性国家科学中心大健康研究院

科学研究

肿瘤免疫与抗体药物中心

马思聪

大健康研究院副研究员

联系方式： E-mail：s.ma@ihm.ac.cn

个人简介：

马思聪，2019年博士毕业于德国海德堡大学医学院，获最优等荣誉学位Summa cum laude。 2019-2022于德国国家癌症中心从事博士后研究，主要研究方向是肿瘤免疫和T细胞新型免疫检查点的开发和机制研究。2023年入职合肥综合性国家科学中心大健康研究院任副研究员。主要代表成果以第一作者或通讯作者发表在Immunity，Science Immunology，Cellular＆Molecular Immunology等期刊。入选第一届教育部人才项目和安徽省人才项目。

研究兴趣及方向：

主要研究方向是T细胞新型免疫检查点的开发和临床应用；肿瘤微环境中的免疫抑制因素与T细胞免疫反应的互作及机制研究。

代表性工作：

1. Wu, J#., Ma, S#., Sandhoff, R#., Ming, Y., Hotz-Wagenblatt, A., Timmerman, V., ... & Cui, G. 2019. Loss of neurological disease HSAN-I-associated gene SPTLC2 impairs CD8+ T cell responses to infection by inhibiting T cell metabolic fitness. Immunity, 505, 1218-1231.#共同第一作者

2. Ma, S#*., Sandhoff, R#., Luo, X#., Shang, FW#....... & Cui, G*. 2024. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos. Science Immunology, 994:eadg8817.#共同第一作者*通讯作者

3. Ma S#, Ming Y#, Wu J, et al. Cellular metabolism regulates the differentiation and function of T-cell subsets. 2024. Cellular & Molecular Immunology, 2024: 1-17. #共同第一作者

4. Weisshaar, N., Ma, S., Ming, Y., Madi, A., Mieg, A., Hering, M., ... & Cui, G. 2023. The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate. Nature Immunology, 2411, 1921-1932.

5. Wu, J., Weisshaar, N., Hotz-Wagenblatt, A., Madi, A., Ma, S., Mieg, A., ... & Cui, G. 2020. Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion. Science Advances, 624, eaba3458

6. Wu, J., Madi, A., Mieg, A., Hotz-Wagenblatt, A., Weisshaar, N., Ma, S., ... & Cui, G. 2020. T cell factor 1 suppresses CD103+ lung tissue-resident memory T cell development. Cell reports, 311, 107484.

7. Ma, S#., Ding, M#., Li, J#., Wang, T., Qi, X., Shi, Y., Ming, Y., Chi, J., Wang, Z., Tang, X. and Cui, D., 2017. Ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma: clinical outcomes and prognostic factors. Journal of cancer research and clinical oncology, 1431, pp.131-142. #共同第一作者

8. Ding, M#., Ma, S#., Tang, X#., Wang, T., Qi, X., Chi, J., Wang, Z., Cui, D., Shi, Y., Zhang, Y. and Li, P., 2018. Oliguric acute kidney injury after microwave ablation of large liver tumors: incidence and preventive measures. International Journal of Hyperthermia, 351, pp.141-149. #共同第一作者

9. Shen, X., Ma, S#., Tang, X., Wang, T., Qi, X., Chi, J., Wang, Z., Cui, D., Zhang, Y., Li, P. and Zhai, B., 2018. Clinical outcome in elderly Chinese patients with primary hepatocellular carcinoma treated with percutaneous microwave