郑小虎，男，教授，博士生导师，国家基金委优秀青年基金获得者，安徽省杰青获得者。2009本科毕业于安徽医科大学，2015年博士毕业于中国科学技术大学，毕业后一直在中国科学技术大学免疫学研究所工作。2022年聘任合肥综合性国家科学中心大健康研究院大分子平台主任。主要从事NK细胞与免疫微环境研究，相关成果以（共）通讯/第一作者发表在Nat Immunol 2篇、PNAS、Cancer Res2篇、Clinic Cancer Res、Nati Sci Rev、Cell Mol Immunol 2篇和J Hematol Oncol 等学术期刊，获中国科学院院长优秀奖和中国免疫学会青年学者奖。

1. NK细胞与肿瘤免疫微环境

2. 肿瘤/炎症免疫干预靶点的寻找与药物研发

1. Xiaohu Zheng#*, Zhuanghao Hou#, Yeben Qian, Yongwei Zhang, Quanwei Cui, Xuben Wang, Yiqing Shen, Zhenbang Liu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian*, Guangming Huang* and Haiming Wei*.Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nature Immunology. 2023 Mar 23.

2. Dong Wang #, Xiaohui Li #, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen, Yichen Lu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Xiaohu Zheng*, Haiming Wei*. J Hematol Oncol. 2023 Mar 27.

3. Defeng Jiao, Xiaohu Zheng*, Xianghui Du, Dong Wang, Ziming Hu, Rui Sun, Zhigang Tian, Binqing Fu*, and Haiming Wei*, Immunogenic senescence sensitizes lung cancer to LUNX-targeting therapy. Cancer Immunol Immunother. 2022 Jun;716:1403-1417.

4. Sanyou Chen#, Wanhe Li#, Xiaohu Zheng#, Pei Yu, Pengfei Wang, Ziting Sun, Yao Xu, Defeng Jiao, Xiangyu Ye, Mingcheng Cai, Mengze Shen, Mengqi Wang, Qi Zhang, Fei Kong, Ya Wang, Jie He, Haiming Wei, Fazhan Shi*, and Jiangfeng Du*, Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond. Proc Natl Acad Sci USA. 2022 Feb 1;1195:e2118876119.

5. Xiaohu Zheng*, Yaqi Wu, Jiacheng Bi, Yingying Huang, Ying Cheng, Yangyang Li, Yuwei Wu, Guoshuai Cao, Zhigang Tian*, The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy. 2021 Dec 12. Cell Mol Immunol. 2022 Feb;192:192-209

6. Zhigang Nian, Xiaohu Zheng*, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei*, Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells, Clinic Cancer Research, 2021 Nov 1;2721:6026-6038

7. Jiacheng Bi, Chaoyue Zheng and Xiaohu Zheng*. Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells. Cell Mol Immunol. 2021, DOI: 10.1038/s41423-020-00632-1.

8. Xiaohu Zheng, Haiming Wei*. Organ-Specific Immune-Related Adverse Events for PD-1 Antibodies in Lung Cancer Treatment. 2021, Front Oncol, DOI: 10.3389/fonc.2021.628243. IF=6.242

9. Yonggang Zhou#; Binqing Fu#; Xiaohu Zheng#; Dongsheng Wang; Changcheng Zhao; Yingjie qi; Rui Sun; Zhigang Tian; Xiaoling Xu*; Haiming Wei*. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. National Science Review. 2020, DOI:10.1093/nsr/nwaa041. IF=17.275

10. Xin Zhang, Dong Wang, Zhidong Li, Defeng Jiao, Linlin Jin, Jingjing Cong, Xiaohu Zheng* and Lijun Xu*. Low-Dose Gemcitabine Treatment Enhances Immunogenicity and Natural Killer Cell-Driven Tumor Immunity in Lung Cancer. Front Immunol, Feb 2020, Volume 11. IF=7.562

11. Xiaohu Zheng, Yeben Qian, Binqing Fu, Defeng Jiao, Yong Jiang, Peng Chen, Yiqing Shen, Huafeng Zhang, Rui Sun, Zhigang Tian* and Haiming Wei *, Mitochondrial fragmentation limits natural killer cell-based tumour immunosurveillance. Nature Immunology, 2019 Dec, 20;1656-1667. IF=25.6

12. Yong Jiang#, Xiaohu Zheng#, Defeng Jiao, Peng Chen, Yechuan Xu, Haiming Wei*, Yeben Qian*. Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma. EBioMedicine, 2019 Feb;40:422-431. IF=8.141

13. Xiaohu Zheng , Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*, EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Research, JAN 15 2017, 77; 482-493. IF=12.703

14. Xiaohu Zheng, Min Cheng, Binqing Fu, Xiaolei Fan, Qing Wang, Xiaoqing Yu, Rui Sun, Zhigang Tian*, Haiming Wei*. Targeting LunX inhibits non-small-cell lung cancer growth and metastasis. Cancer Research, March 15, 2015 75; 1080-90. IF=12.533

15. Xiaohu Zheng, Zhigang Tian, Haiming Wei*. Lung specific X protein as a novel therapeutic target for lung cancer. OncoImmunology, 2015 Aug 17;412:e1052931.