黄鑫，女，2017年初在中科院上海生命科学研究院获得博士学位。随后在美国St. Jude Children’s Research Hospital 从事Garwood Fellowship 博士后研究。研究工作主要是在儿童实体瘤和白血病队列中整合多组学数据，发现新的药物靶点或克服药物抗性的联合用药策略，以第一或共同第一作者身份在Developmental Cell, Nature Communications, JBC 等期刊发表学术论文。产业方面和曾经的导师、Amgen PROTAC 平台负责人 Ryan Potts（Scientific Vice President）建立了稳定的合作关系，将进一步针对感兴趣的肿瘤靶点开发PROTAC 分子（蛋白降解靶向嵌合体）。

儿童肿瘤已经成为严重威胁中国儿童健康的主要公共卫生问题。本实验室通过生物信息，生物物理，细胞与分子生物学等手段，发掘儿童肿瘤中新的药物靶点或克服药物抗性的联合用药策略并开发相关PROTAC药物。为诊断和治疗的临床转化提供新的策略。

1. Yang, S. W., Huang, X. *, Lin, W., Min, J., Miller, D. J., Mayasundari, A., Rodrigues, P., Griffith, E. C., Gee, C. T., Li, L., Li, W., Lee, R. E., Rankovic, Z., Chen, T. & Potts, P. R. Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat Commun 11, 4931 2020. （proof-of-principle PoP 开发基于MAGE的靶向肿瘤细胞而非正常细胞的PROTAC分子）

2.Patel, A. G., Chen, X., Huang, X. *, Clay, M. R., Komorova, N., Krasin, M. J., Pappo, A., Tillman, H., Orr, B. A., McEvoy, J., Gordon, B., Blankenship, K., Reilly, C., Zhou, X., Norrie, J. L., Karlstrom, A., Yu, J., Wodarz, D., Stewart, E. & Dyer, M. A. The myogenesis program drives clonal ion and drug resistance in rhabdomyosarcoma. Dev Cell 57, 1226-1240 e1228 2022.（在实体瘤和白血病队列中整合多组学数据，发现新的药物靶点或克服药物抗性的靶点）

3. Huang, X., Zheng, Y., Zhang, F., Wei, Z., Wang, Y., Carrell, R. W., Read, R. J., Chen, G. Q. & Zhou, A. Molecular Mechanism of Z alpha1-Antitrypsin Deficiency. J Biol Chem 291, 15674-15686 2016.（应用生物物理，结构，细胞与分子生物学手段，研究疾病中小分子药物与靶蛋白的相互作用机制） 

4. Liu, C. X., Yin, Q. Q., Zhou, H. C., Wu, Y. L., Pu, J. X., Xia, L., Liu, W., Huang, X., Jiang, T., Wu, M. X., He, L. C., Zhao, Y. X., Wang, X. L., Xiao, W. L., Chen, H. Z., Zhao, Q., Zhou, A. W., Wang, L. S., Sun, H. D. & Chen, G. Q. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol 8, 486-493 2012. 

5. Zhu, Z., Li, C., Zeng, Y., Ding, J., Qu, Z., Gu, J., Ge, L., Tang, F., Huang, X., Zhou, C., Wang, P., Zheng, D. & Jin, Y. PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs. Cell Stem Cell 20, 274-289 e277 2017. 

6. Gocho, Y., Liu, J., Hu, J., Yang, W., Dharia, N. V., Zhang, J., Shi, H., Du, G., John, A., Lin, T. N., Hunt, J., Huang, X., Ju, B., Rowland, L., Shi, L., Maxwell, D., Smart, B., Crews, K. R., Yang, W., Hagiwara, K., Zhang, Y., Roberts, K., Wang, H., Jabbour, E., Stock, W., Eisfelder, B., Paietta, E., Newman, S., Roti, G., Litzow, M., Easton, J., Zhang, J., Peng, J., Chi, H., Pounds, S., Relling, M. V., Inaba, H., Zhu, X., Kornblau, S., Pui, C. H., Konopleva, M., Teachey, D., Mullighan, C. G., Stegmaier, K., Evans, W. E., Yu, J. & Yang, J. J. Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia. Nat Cancer 2, 284-299 2021.

7. Zhao, X., Wang, P., Diedrich, J. D., Smart, B., Reyes, N., Yoshimura, S., Zhang, J., Yang, W., Barnett, K., Xu, B., Li, Z., Huang, X., Yu, J., Crews, K., Yeoh, A. E. J., Konopleva, M., Wei, C. L., Pui, C. H., Savic, D. & Yang, J. J. Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Nat Commun 13, 5401 2022. 

8. Li, Z., Chang, T. C., Junco, J. J., Devidas, M., Li, Y., Yang, W., Huang, X., Hedges, D. J., Cheng, Z., Shago, M., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Wood, B. L., Borowitz, M. J., Sanclemente, L., Raetz, E. A., Hunger, S. P., Feingold, E., Rosser, T. C., Sherman, S. L., Loh, M. L., Mullighan, C. G., Yu, J., Wu, G., Lupo, P. J., Rabin, K. R. & Yang, J. J. Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia. Blood 2023. 

9. Ding, L., Shi, H., Qian, C., Burdyshaw, C., Veloso, J. P., Khatamian, A., Pan, Q., Dhungana, Y., Xie, Z., Risch, I., Yang, X., Huang, X., Yan, L., Rusch, M., Brewer, M., Yan, K. K., Chi, H. & Yu, J. scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data. bioRxiv, 2023.2001. 2026.523391 2023.