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基因治疗药物中心
实验动物平台主任、高级工程师
个人简介：
江龙，男，2017年中国科学技术大学博士毕业，博士阶段主要致力于生殖系统遗传突变的人源化小鼠模型构建，以及精子发生和减数分裂机制的探究；2017年至2022年于美国密歇根大学（University of Michigan）进行博士后研究，主要致力于靶向全基因组的高通量CRISPR筛选，探索抗肿瘤免疫治疗新靶点及其作用机制。具有丰富的遗传学、肿瘤生物学及免疫学相关研究经验，擅长基因编辑技术的应用和优化。近五年，在Current Biology 等国际主流期刊上发表过研究论文。
研究兴趣及方向：
1. 基因编辑技术优化和疾病相关动物模型开发
2. 基于动物模型的药物药效分析和毒理研究
3. 基于动物模型和CRISPR筛选的新靶点发现和创新药开发
代表性工作：
1. Jiang L*, Li T*, Zhang X, Zhang B, Yu C, Li Y, Fan S, Jiang X, Khan T, Hao Q, Peng Xu, Nadano D, Huleihel M, Lunenfeld E, Wang PJ, Zhang Y#, and Shi Q#. RPL10L is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Current Biology. 2017 May 22;2710:1498-1505.e6.
2. Ma H*, Li T*, Xie X*, Jiang L, Ye J, Gong C, Jiang H, Fan S, Zhang H, Shi B, Zhang B, Jiang X, Li Y, Zhou J, Xu J, Zhang X, Hou X, Yin H#, Zhang Y#, Shi Q#. RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes. Science Advances. 2022 Jan 14;82: eabk1789.
3. Yu J*, Green MD*#, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W#. Liver metastasis restrains immunotherapy efficacy via macrophage- mediated T cell elimination. Nature Medicine. 2021 Jan;271:152-164.
4. Lang X*, Green MD*, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I1, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W#. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discovery. 2019 Dec;912:1673-1685.
5. Huang Y*, Jiang L, Yi Q, Lv L, Wang Z, Zhao X, Zhong L, Jiang H, Rasool S, Hao Q, Guo Z, Cooke HJ, Fenech M, Shi Q#. Lagging chromosomes entrapped in micronuclei are not 'lost' by cells. Cell Research. 2012 May;225:932-5.
