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大健康研究院 高级研究员
个人简介：
张鹏，男，国家级人才项目（2022）获得者，2007年毕业于北京师范大学生命科学学院，生命科学专业，获理学学士学位； 2013年毕业于中国科学院生物物理研究所，细胞生物专业，获理学博士学位；2013至2023年在美国国立卫生研究院National Institutes of Health, NIH，国立过敏及感染性疾病研究所National Institute of Allergy and Infectious Diseases,NIAID，担任访问学者Visiting Fellow（博士后），研究学者Research Fellow及职员科学家Staff Scientist。2023年8月入职合肥综合性国家科学中心大健康研究院。研究方向包括：艾滋病mRNA疫苗设计，动物模型验证，免疫调控机制。最近五年学术文章（以第一作者身份）主要发表于Nature Medicine, Cell Host & Microbe, Proceedings of National Academy of Sciences等期刊。
研究兴趣及方向：
1. 探索艾滋病病毒mRNA或其他类型疫苗在灵长类动物免疫应答，开展相关疫苗临床试验，及试验数据分析
2. 阐明分析病毒进化方式，胞膜糖蛋白与中和抗体作用原理，疫苗抗原设计优化
3. 研发相关试剂及抗体
代表性工作：
1. Zhang P, Narayanan E, Liu Q, Tsybovsky Y, Boswell K, Ding S, Hu Z, Follmann D, Lin Y, Miao H, Schmeisser H, Rogers D, Falcone S, Elbashir SM, Presnyak V, Bahl K, Prabhakaran M, Chen X, Sarfo EK, Ambrozak DR, Gautam R, Martin MA, Swerczek J, Herbert R, Weiss D, Misamore J, Ciaramella G, Himansu S, Stewart-Jones G, McDermott A, Koup RA, Mascola JR, Finzi A, Carfi A, Fauci AS, Lusso P. A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques. Nat. Med. 2021 Dec 9. 2712,2234–2245. doi: 10.1038/s41591-021-01574-5.PMID: 34887575. Cover Article with accompanying Editorial: Nat. Med. 2021 Dec 9. 27:2082-4.
2. Zhang P, Gorman J, Geng H, Liu Q , Lin Y, Tsybovsky Y, Go E, Dey B, Andine T, Kwon A, Patel M, Gururani D, Uddin F, Guzzo G, Cimbro R, Miao H, McKee K, Chuang G, Martin L, Sironi F, Malnati M, Desaire H, Berger EA, Mascola J, Seedorff J, Dolan MA, Kwong PD, Lusso P. Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer. Cell Host & Microbe. 2018 Jun 13;236:832-844.e6. doi: 10.1016/j.chom.2018.05.002. with accompanying Editorial: Cell Host & Microbe. 2018 Jun 13 DOI: 10.1016/j.chom.2018.05.017.
3. Zhang P, Falcone S, Tsybovsky Y, Singh M, Gopan V, Miao H, Seo Y, Rogers D, Renzi I, Lai Y, Narayanan, Stewart-Jones G, Himansu S, Carfi A, Fauci A, Lusso P. Increased neutralization potency and breadth elicited by a SARS-CoV-2 mRNA vaccine forming virus-like particles. Proc Natl Acad Sci U S A. July 10, 2023;120 29 e2305896120. doi: doi.org/10.1073/pnas.2305896120. PMID: 37428933.
4.Zhang P, Kwon AL, Guzzo C, Liu Q, Schmeisser H, Miao H, Lin Y, Cimbro R, Huang J, Connors M, Schmidt SD, Dolan MA, Armstrong AA, Lusso P. Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State. mBio. 2021 Mar 30;122:e00090-21. doi: 10.1128/mBio.00090-21.
5.Le Nouen C, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Yang L, Herbert R, Castens A, Moore IN, Wilder-Kofie T, Moore R, Walker A, Zhang P, Lusso P, Johnson RF, Garza NL, Via LE, Munir S, Barber D, Buchholz UJ. Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques. Cell. 2022 Dec 8;18525:4811-4825.e17. doi: 10.1016/j.cell.2022.11.006. Epub 2022 Nov 10. PMID: 36423629
6. Liu X, Park HS, Matsuoka Y, Santos C, Yang L, Luongo C, Moore IN, Johnson RF, Garza NL, Zhang P, Lusso P, Best SM, Buchholz UJ, Nou?n CL.Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters. PloS Pathog. 2023 Jun 23;196:e1011057. doi: 10.1371/journal.ppat.1011057.eCollection 2023 Jun. PMID: 37352333.
7. Liu Q, Miao H, Li S, Zhang P, Gerber GF, Follmann D, Ji H, Zeger SL, Chertow DS, Quinn TC, Robinson ML, Kickler TS, Rothman RE, Fenstermacher KZJ, Braunstein EM, Cox AL, Farci P, Fauci AS, Lusso P. Proc Natl Acad Sci U S A. 2022 Nov 22;11947:e2213361119. doi: 10.1073/pnas.2213361119. Epub 2022 Nov 2. PMID: 36322776
8. Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, Zhang B, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P. Potent monoclonal antibodies neutralize Omicron and other SARS-CoV-2 variants. Cell Rep. 2022 Nov 1;415:111528. doi: 10.1016/j.celrep.2022.111528. Epub 2022 Sep 30.PMID: 36302375
