吴晶霞，女，国家级人才项目（2022）获得者，2005年毕业于南京大学生命科学研究院，生物技术专业（生化药学强化班），获理学学士学位；2012年毕业于中国科学院上海生命科学研究院，生物化学与分子生物学专业，获理学博士学位；2012至2014年在美国耶鲁大学医学院心血管研究中心从事博士后研究；2016至2023年在德国癌症研究中心从事博士后研究，2023年6月入职合肥综合性国家科学中心大健康研究院。主要研究糖脂代谢信号通路及糖脂代谢对抗病毒、抗肿瘤免疫反应的调控机制。现发表学术论文22篇，其中第一作者身份论文发表在Immunity, Science Translational Medicine, Science Advances等期刊。

1. 探索糖脂代谢及糖脂代谢相关疾病对抗病毒、抗肿瘤免疫反应的影响，尤其是对CD8+ T细胞分化和功能调控的影响

2. 阐明在抗病毒、抗肿瘤免疫反应中代谢分子对T细胞分化和功能调控的作用机制

3. 开发以代谢分子为靶点的增强T细胞抗病毒、抗肿瘤功能的小分子或蛋白药物

1. Wu J#, Ma S#, Sandhoff R#, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Loscher WN, Reindl M, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity 2019;50:1218-31 e5. # co-first author.

2. Wu J, Weisshaar N, Hotz-Wagenblatt A, Madi A, Ma S, Mieg A, Hering M, Mohr K, Schlimbach T, Borgers H, Cui G. Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion. Science Advances 2020;6:eaba3458.

3. Hwangbo C#, Wu J#, Papangeli I, Adachi T, Sharma B, Park S, Zhao L, Ju H, Go GW, Cui G, Inayathullah M, Job JK, et al. Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects. Science Translational Medicine 2017;9. # co-first author.

4. Wu J, Madi A, Mieg A, Hotz-Wagenblatt A, Weisshaar N, Ma S, Mohr K, Schlimbach T, Hering M, Borgers H, Cui G. T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development. Cell Reports 2020;31:107484.

5. Wu J, Zhang F, Yan M, Wu D, Yu Q, Zhang Y, Zhou B, McBurney MW, Zhai Q. WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis. Diabetes 2011;60:3197-207.

6. Wu J, Ma S, Hotz-Wagenblatt A, Angel P, Mohr K, Schlimbach T, Schmitt M, Cui G. Regulatory T cells sense effector T-cell activation through synchronized JunB expression. FEBS Letters 2019;593:1020-29.

7. Weisshaar N, Wu J, Ming Y, Madi A, Hotz-Wagenblatt A, Ma S, Mieg A, Hering M, Zettl F, Mohr K, Schlimbach T, Ten Bosch N, Hertel F, Müller L, Byren H, Wang M, Borgers H, Munz M, Schmitt L, van der Hoeven F, Kloz U, Carretero R, Schleu?ner N, Jackstadt R, Hofmann I, Cui G. Rgs16 promotes antitumor CD8+ T cell exhaustion. Science Immunology 2022;7:eabh1873.

8. Madi A, Wu J, Ma S, Weisshaar N, Mieg A, Hering M, Ming Y, Zettl F, Mohr K, Ten Bosch N, Schlimbach T, Hertel F, Cui G. Regulatory T cell-derived interleukin-15 promotes the diversity of immunological memory. Eur J Immunol 2023;53:e2149400.

9. Mehrotra D, Wu J, Papangeli I, Chun HJ. Endothelium as a gatekeeper of fatty acid transport. Trends Endocrinol Metab 2014;25:99-106.

10. Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. Cell 2015;161:750-61.

11. Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circulation Research 2013;113:22-31.

12. Zhou B, Zhang Y, Zhang F, Xia Y, Liu J, Huang R, Wang Y, Hu Y, Wu J, Dai C, Wang H, Tu Y, Peng X, Wang Y, Zhai Q. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology 2014;59:2196-206.

13. Madi A, Weisshaar N, Buettner M, Poschet G, Ma S, Wu J, Mieg A, Hering M, Ming Y, Mohr K, Ten Bosch N, Cui G. CD8 agonism functionally activates memory T cells and enhances antitumor immunity. Int J Cancer 2022;151:797-808.

14. Lamas-Murua M, Stolp B, Kaw S, Thoma J, Tsopoulidis N, Trautz B, Ambiel I, Reif T, Arora S, Imle A, Tibroni N, Wu J, Cui G, Stein J, Tanaka M, Lyck R, Fackler O. HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface. J Immunol 2018;201:2731-43.

15. Kim JD, Kang Y, Kim J, Papangeli I, Kang H, Wu J, Park H, Nadelmann E, Rockson SG, Chun HJ, Jin SW. Essential role of Apelin signaling during lymphatic development in zebrafish. Arterioscler Thromb Vasc Biol 2014;34:338-45.

16. Zhang Y, Zhou B, Deng B, Zhang F, Wu J, Wang Y, Le Y, Zhai Q. Amyloid-beta induces hepatic insulin resistance in vivo via JAK2. Diabetes 2013;62:1159-66.

17. Zhang Y, Zhou B, Zhang F, Wu J, Hu Y, Liu Y, Zhai Q. Amyloid-beta induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 2012;61:1434-43.

18. Zhou B, Li C, Qi W, Zhang Y, Zhang F, Wu J, Hu Y, Wu D, Liu Y, Yan T, Jing Q, Liu M, Zhai Q. Downregulation of miR-181a upregulates sirtuin-1 SIRT1 and improves hepatic insulin sensitivity. Diabetologia 2012;55:2032-43.

19. Yan M, Wang Y, Hu Y, Feng Y, Dai C, Wu J, Wu D, Zhang F, Zhai Q. A high-throughput quantitative approach reveals more small RNA modifications in mouse liver and their correlation with diabetes. Anal Chem 2013;85:12173-81.

20. Liu Y, Zhou D, Zhang F, Tu Y, Xia Y, Wang H, Zhou B, Zhang Y, Wu J, Gao X, He Z, Zhai Q. Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis. J Lipid Res 2012;53:358-67.

21. Yu Q, Wang T, Zhou X, Wu J, Chen X, Liu Y, Wu D, Zhai Q. WldS reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD. PLoS One 2011;6:e21770.

22. Zhang F, Sun C, Wu J, He C, Ge X, Huang W, Zou Y, Chen X, Qi W, Zhai Q. Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice. Pharmacol Res 2008;57:318-23.