周志伟，男，2011年本科毕业于南方医科大学基础医学院，2018年初在中科院广州生物医药与健康研究院获得博士学位。随后在北京生命科学研究所邵峰院士实验室从事博士后研究。2023年6月加入合肥综合性国家科学中心大健康研究院。研究工作主要聚焦在细胞焦亡（pyroptosis）与肿瘤免疫的关系，研究成果以第一或共同第一作者身份发表在Science, Nature, Methods Mol Biol, Cell Reports等期刊。入选中国科协第六届青年人才托举工程。

本实验室通过遗传筛选、生化、化学生物学等手段探究细胞程序性死亡的分子机制，旨在探索细胞程序性死亡与疾病，肿瘤的关系。此外，课题组还聚焦于机体的抗肿瘤免疫过程，旨在探究崭新的肿瘤免疫逃逸机制和发现全新的药物靶点。

1. Zhiwei Zhou, Yupeng Wang, Feng Shao. Inducing Pyroptosis via Gasdermin B and Gasdermin E Cleavage. Methods Mol Biol. 2023

2.  Xiu Zhong*, Huan Zeng*, Zhiwei Zhou*, Ya Su, Hang Cheng, Yanjie Hou, Yang She, Na Feng, Jia Wang, Feng Shao, Jingjin Ding. Structural mechanism for regulations of GSDMB pore-forming activity. Nature. 2023 Apr * Co-first author.

3. Zhiwei Zhou*, Huabin He*, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, Weidong Han, Lin Shen, Jingjin Ding, Feng Shao. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science. 2020 Apr * Co-first author.

4. Yue Xu, Ping Zhou, Sen Cheng, Qiuhe Lu, Kathrin Nowak, Ann-Katrin Hopp, Lin Li, Xuyan Shi, Zhiwei Zhou, Wenqing Gao, Da Li, Huabin He, Xiaoyun Liu, Jingjin Ding, Michael O. Hottiger, and Feng Shao. A Bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy. Cell. 2019 Jul.

5. Zhiwei Zhou, Xuejie Yang, Jiangping He, Jing Liu, Fang Wu, Shengyong Yu, Yuting Liu, Runxia Lin, He Liu, Yuanbin Cui, Chunhua Zhou, Xiaoshan Wang, Jian Wu, Shangtao Cao, Lin Guo, Lihui Lin, Tao Wang, Xiaozhong Peng, Boqing Qiang, Andrew P. Hutchins, Duanqing Pei, and Jiekai Chen. Kdm2b regulates somatic reprogramming through variant PRC1 complex-dependent function. Cell Reports. 2017 Nov.