纪德彬，2012年毕业于中国科学院大连化学物理研究所并获得博士学位；2012-2018年分别在加州大学河滨分校和斯坦福大学从事博士后研究工作。2018年回国在山东大学任研究员和博士生导师。2024年3月加入合肥综合性国家科学中心大健康研究院担任特任研究员。主要研究方向为核苷酸与核酸的化学修饰。现发表学术论文32篇，研究成果以第一作者或通讯作者发表在JACS，ACIE，Nucleic Acids Research等杂志。

利用有机化学，化学生物学的方法设计合成修饰的核苷酸和核酸类化合物，用于疾病的诊断和治疗。另外，探索蛋白质与核酸的共价偶联及其在生物医学中的应用。

1. Ji DB, Beharry AA, Ford JM, Kool ET. A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target. J. Am. Chem. Soc. 2016, 138, 9005–9008.

2. Ji DB, Mohsen MG, Harcourt EM, Kool ET. ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling. Angew. Chem. Int. Ed. 2016, 55, 2087–2091.  Hot paper

3. Ji DB, Wang L, Hou SH, Liu WJ, Wang JX, Wang Q, Zhao ZB. Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine Dinucleotide. J. Am. Chem. Soc. 2011, 133, 20857–20862.

4. Ji DB, Stepchenkova E, Cui J, Menezes M, Pavlov Y, Kool ET. Measuring Deaminated Nucleotide Surveillance Enzyme ITPA Activity with an ATP-releasing Nucleotide Chimera. Nucleic Acids Res. 2017 45, 11515–11524.

5. Mohsen MG^#, Ji DB^#, Kool ET. Polymerase synthesis of four-base DNA from two stable dimeric nucleotides. Nucleic Acids Res. 2019, 48, 9495–9501. # Co-first author.

6. Shao YT, Chen MM, Chen WL, Wang ZH, Sui  MZ, Tian MY, Wu YN, Song JT*, Ji DB*, Song FL*. Integration of Activation by Hypoxia and Inhibition Resistance of Tumor cells to Apoptosis for Precise and Augmented Photodynamic Therapy. Adv. Healthc. Mater. 2023, 12, 202300503.

7. Meng J, Guo QQ, Zhai XN, Yang S, Wang S, Wang PC, Ji DB* A Phosphamide Nucleotide Analog: a Substrate for Polymerase Synthesis of DNA. Org. Biomol. Chem. 2024, 22, 2963–2967.