2017年7月博士毕业清华大学生命科学学院，师从戴俊彪教授进行合成生物学技术研究，国奖获得者；2017年7月-2023年5月任职于北京合生基因科技有限公司，主要从事溶瘤病毒载体优化开发、核酸药物研发等工作；2024年12月加入大健康研究院医疗器械与普惠医疗研究所王育才课题组，开展新型核酸药物研发工作。 主导和参与的研究工作发表在Nucleic Acids Research，Nature communications， Science等。

新型核酸药物的分子设计、核酸药物的精准调控。

1 Yakun Guo^#; Junkai Dong^#; Tong Zhou^#; Jamie Auxillos^#; Tianyi Li; Weimin Zhang; Lihui Wang; Yue Shen; Yisha Luo; Yijing Zheng; Jiwei Lin; Guo-Qiang Chen; Qingyu Wu; Yizhi Cai; Junbiao Dai ; YeastFab: the design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae, Nucleic Acids Research, 2015, 4313: e88

 2 Huiya Huang^#; Yiqi Liu^#; Weixi Liao^#; Yubing Cao; Qiang Liu; Yakun Guo; Yinying Lu; Zhen Xie ; Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy, Nature Communications, 2019, 10: 4801

 3 Zhang, Weimin^#; Zhao, Guanghou^#; Luo, Zhouqing^#; Lin, Yicong; Wang, Lihui; Guo, Yakun; Wang, Ann; Jiang, Shuangying; Jiang, Qingwen; Gong, Jianhui; Wang, Yun; Hou, Sha; Huang, Jing; Li, Tianyi; Qin, Yiran; Dong, Junkai; Qin, Qin; Zhang, Jiaying; Zou, Xinzhi; He, Xi; Zhao, Li; Xiao, Yibo; Xu, Meng; Chen ; Engineering the ribosomal DNA in a megabase synthetic chromosome, Science, 2017, 6329355: eaaf3981

4 Yuan, Ting^#; Guo, Yakun^#; Dong, Junkai; Li, Tianyi; Zhou, Tong; Sun, Kaiwen; Zhang, Mei; Wu, Qingyu; Xie, Zhen; Cai, Yizhi; Cao, Limin; Dai, Junbiao ; Construction, characterization and application of a genome-wide promoter library in Saccharomyces cerevisiae, Frontiers Of Chemical Science And Engineering, 2017, 111: 107-116

5 Luo, Zhouqing; Wang, Lihui; Wang, Yun; Zhang, Weimin; Guo, Yakun; Shen, Yue; Jiang, Linghuo; Wu, Qingyu; Zhang, Chong; Cai, Yizhi; Dai, Junbiao ; Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES, Nature Communications, 2018, 99: 1930