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传染病与疫苗药物中心
大健康研究院 院长助理、资深研究员
个人简介：
金腾川，男，1980年出生，博士。多年来一直从事感染与免疫分子机制及抗体药物生物技术免疫调控策略等方向研究，在Immunity, J Exp Med, Nature Commun, Sig Trans Targ Ther, Nucleic Acids Res, Protein & Cell, CMI, Cell Rep 等国际学术期刊发表论文100余篇，引用次数超过6000次，H-index为34。
研究兴趣及方向：
感染与免疫的分子机制，病原体与宿主相互作用，蛋白质工程和蛋白药物研发
代表性工作：
1. Cong M#, Yang Y#, Tong H, Shimu AS, Wang B, Li Q, Li F, Yang Y, Jin T*, Li B* 2022. 3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-CoV-2 infection. Signal Transduct Target Ther. 71:84. doi: 10.1038/s41392-022-00937-9.
2. Zou J, Li L, Zheng P, Liang W, Hu S, Zhou S, Wang Y, Zhao J, Yuan D, Liu L, Wu D, Xu M, Zhang F, Zhu M, Wu Z, Cao X, Ni M, Ling X, Wu Y, Kuang Z, Hu M, Li J, Li X, Guo X, Xu T, Jiang H, Gao C, Yu M, Liu J, Zhong N, Zhou J*, Huang JA*, Jin T*, He J* 2022. Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance. J Clin Invest. 1324:e154987. doi: 10.1172/JCI154987.
3. Zhang H, Deng S, Ren L, Zheng P, Hu X, Jin T*, Tan X* 2021. Profiling CD8 + T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants. Cell Rep. 3611:109708. doi: 10.1016/j.celrep.2021.109708.
4. Ma H, Zeng W, Meng X, Huang X, Yang Y, Zhao D, Zhou P, Wang X, Zhao C, Sun Y, Wang P, Ou H, Hu X, Xiang Y, Jin T* 2021. Potent Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain. J Virol. 9510:e02438-20. doi: 10.1128/JVI.02438-20.
5. Fan X, Jiang J, Zhao D, Chen F, Ma H, Smith P, Unterholzner L, Xiao T.S, Jin T* 2021. Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Res. 495:2959-2972 doi: 10.1093/nar/gkab076.
