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微生物与合成生物学研究中心
副研究员
个人简介：
2019年博士毕业于中国科学技术大学；2019-2021年于中国科学技术大学从事纳米催化研究；2021-2025年于中国科学院深圳先进技术研究院从事合成生物学研究；2024年加入大健康研究院微生物与合成生物学研究中心曾杰教授课题组。致力于耦合化学-生物过程，实现碳基小分子合成高附加值食品药品等。近五年主持国家自然科学基金青年科学基金项目1项，安徽省自然科学基金青年项目1项，博士后面上项目1项及站中项目1项，并作为骨干参与国家重点研发计划2项，安徽省科技攻坚计划项目1项。迄今已在包括JACS，ANGEW等SCI高水平期刊上发表论文19篇，参与授权专利8项。作为主要参与人，获得第二十二届英国国际发明展（the 22nd annual British Invention Show）中多项大奖，包括年度国际发明“钻石奖”、自然地球奖“铂金奖”和工业“金奖”。
研究兴趣及方向：
1. 细胞代谢重塑：利用代谢工程和进化工程重塑细胞代谢模式；
2. 细胞工厂构建：构建微生物细胞工厂合成高附加值化学品；
代表性工作：
1. Wang, M.; Wang, L.; Li, H.; Du, W.; Khan, M. U.; Zhao, S.; Ma, C.; Li, Z. and Zeng, J.* Ratio-controlled synthesis of CuNi octahedra and nanocubes with enhanced catalytic activity. J. Am. Chem. Soc. 2015, 137, 14027-14030.
2. Wang, M.; Luo, L.; Wang, C.; Du, J.; Li, H.* and Zeng, J.* Heterogeneous catalysts toward CO2 hydrogenation for sustainable carbon cycle. Acc. Mater. Res. 2022, 3, 6, 565-571.
3. Zhao, J.?; Wang, M.?; Peng, Y.; Ni, J.; Hu, S.; Zeng, J.* and Chen, Q.* Exploring the strain effect in single particle electrochemistry using Pd nanocrystals. Angew. Chem. Int. Ed. 2023, e202304424.
4. Luo, L.?; Wang, M.?; Cui, Y.; Chen, Z.; Wu, J.; Cao, Y.; Luo, J.; Dai, Y.; Li, W.-X.; Bao, J.* and Zeng, J.* Surface iron species in a palladium-iron intermetallic promote and stabilize CO2 methanation. Angew. Chem. Int. Ed. 2020, 59, 14434-14442.
5. Tang, H.; Wu, L.; Guo, S.; Cao, W.; Ma, W.; Wang, X.; Shen, J.; Wang, M.; Zhang, Q.; Huang, M.; Luo, X.; Zeng, J.; Keasling, J. D.* and Yu, T.* Metabolic engineering of yeast for the production of carbohydrate-derived foods and chemicals from C1-3 molecules. Nature Catal.?2024, 7, 21.
6. Wu, W.; Luo, L.; Li, Z.; Luo, J.; Zhao, J.; Wang, M.; Ma, X.; Hu, S.; Chen, Y.; Chen, W.; Wang, Z.; Ma, C.; Li, H.* and Zeng, J.* The importance of sintering-induced grain boundaries in copper catalysis to improve carbon-carbon coupling. Angew. Chem. Int. Ed.?2024, 63, e202404983.
7. Wu, W.; Luo, J.; Zhao, J.; Wang, M.; Luo, L.; Hu, S.; He, B.; Ma, C.; Li, H.* and Zeng, J.* Facet sensitivity of iron carbides in Fischer-Tropsch synthesis.Nature Commun.?2024, 15, 6108.
8. Du, J.; Zeng, L.; Yan, T.; Wang, C.; Wang, M.; Luo, L.; Wu, W.; Peng, Z.; Li, H. and Zeng, J.* Efficient solvent- and hydrogen-free upcycling of high-density polyethylene into separable cyclic hydrocarbons. Nature Nanotechnol.?2023, 18, 772.
9. Du, J.; Zeng, L.; Yan, T.; Wang, C.; Wang, M.; Luo, L.; Wu, W.; Peng, Z.; Li, H. and Zeng, J.* Efficient solvent- and hydrogen-free upcycling of high-density polyethylene into separable cyclic hydrocarbons. Nature Nanotechnol. 2023, 18, 772.
10. Li, Z.; Wu, W.; Wang, M.; Wang, Y.; Ma, X.; Luo, L.; Chen, Y.; Fan, K.; Pan, Y.; Li, H.* and Zeng, J.* Ambient-pressure hydrogenation of CO2 into long-chain olefins. Nature Commun. 2022, 13, 2396.
11. Ke, J.; Zhao, J,; Chi, M.; Wang, M.; Kong, X.; Chang, Q.; Zhou, W.; Long, C.; Zeng, J. and Geng, Z.* Facet-dependent electrooxidation of propylene into propylene oxide over Ag3PO4 crystals. Nature Commun. 2022, 13, 932.
12. Wu, W.; Wang, Y.; Luo, L.; Wang, M.; Li, Z.; Chen, Y.; Wang, Z.; Chai, J.; Cen, Z.; Shi, Y.; Zhao, J.; Zeng, J. and Li, H.* CO2 hydrogenation over Copper/ZnO single-atom catalysts: water-promoted transient synthesis of methanol. Angew. Chem. Int. Ed. 2022, e202213.
13. Li, R.; Luo, L.; Ma, X.; Wu, W.; Wang, M. and Zeng, J.* Single atoms supported on metal oxides for energy catalysis. J. Mater. Chem. A 2022, 10, 5717.
14. Zhang, Y.*; Huang, X.; Wang, L.; Cao, C.; Zhang, H.; Wei, P.; Ding, H.; Song, Y.; Chen, Z.; Qian, J.; Zhong, S.; Liu, Z.; Wang, M.; Zhang, W.; Jiang, W.; Zeng, J.; Yao, G.* and Wen, L.* Glutathionylation-dependent proteasomal degradation of wide-spectrum mutant p53 proteins by engineered zeolitic imidazolate framework-8. Biomaterials 2021, 271, 120720.
15. Li, H.; Wang, M.; Luo, L. and Zeng, J.* Static regulation and dynamic evolution of single-atom catalysts in thermal catalytic reactions. Adv. Sci. 2019, 6, 1801471.
16. Li, H.; Wang, L.; Dai, Y.; Pu, Z.; Lao, Z.; Chen, Y.; Wang, M.; Zheng, X.; Zhu, J.; Zhang, W.*; Si, R.; Ma, C. and Zeng, J.* Synergetic interaction between neighbouring platinum monomers in CO2 hydrogenation. Nature Nanotechnol. 2018, 13, 411-417.
17. Zhang, W.; Wang, L.; Wang, K.; Khan, M.; Wang, M.; Li, H. and Zeng, J.* Integration of photothermal effect and heat insulation to efficiently reduce reaction temperature of CO2 Hydrogenation. Small 2017, 13, 1602583.
18. Khan, M. U.; Wang, L.; Liu, Z.; Gao, Z.; Wang, S.; Li, H.; Zhang, W.; Wang, M.; Wang, Z.*; Ma, C. and Zeng, J.* Pt3Co octapods as superior catalysts of CO2 hydrogenation. Angew. Chem. Int. Ed. 2016, 55, 9548-9552.
19. Wang, L.; Zhang, W.; Wang, S.; Gao, Z.; Luo, Z.; Wang, X.; Zeng, R.; Li, A.; Li, H.; Wang, M.; Zheng, X.; Zhu, J.; Zhang, W.*; Ma, C.*; Si, R. and Zeng, J.* Atomic-level insights in optimizing reaction paths for hydroformylation reaction over Rh/CoO single-atom catalyst. Nature Commun. 2016, 7, 14036.
