杨冬冬，女，2012年7月毕业于沈阳药科大学（基础药学基地班），获理学学士学位，“沈阳市优秀大学生”；2018年11月毕业于中国科学技术大学，获理学博士学位，国奖获得者。2018年11月至2023年5月于中国科学技术大学从事博士后研究。研究生期间主要从事肿瘤微环境与肿瘤代谢互作研究，博士后期间主要从事肿瘤代谢免疫微环境的相关研究。2023年6月加入大健康研究院先进医药与再生医学研究所朱书课题组，从事肠道微生物相关的代谢研究。主 要研究成果发表于CELL REP, COMPUT METH PROG BIO,  NAT COMMUN, ADV EXP MED BIOL 等期刊。目前主持科研基金共4项，参与4项。

1. 基于MS的肠道微生物代谢研究

2. 基于MSI的肠道空间特征探索

3. 基于MFA的肠道代谢通路研究

1.   Dongdong Yang#, Haiying Liu#, Yongping Cai, Kangyang Lu, Xiuying Zhong, Songge Xing, Wei Song, Yaping Zhang, Ling Ye, Xia Zhu, Ting Wang, Pinggen Zhang, Shi-Ting Li, Jiaqian Feng, Weidong Jia, Huafeng Zhang*, Ping Gao*. Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression. Cell Reports. 2022, 41: 111691.

2.   Dongdong Yang#, Ping Gao*, Chao Tian*, Yang Sheng*. Gompertz tracking of the growth trajectories of the human-liver-cancer xenograft-tumors in nude mice. Computer Methods and Programs in Biomedicine. 2020, 191:105412.

3.  Aoxing Cheng#, Peng Zhang#, Bo Wang#, Dongdong Yang#, Xiaotao Duan, Yongliang Jiang, Tian Xu, Ya Jiang, Jiahui Shi, Chengtao Ding, Gao Wu, Zhihong Sang, Qiang Wu, Hua Wang, Mian Wu, Zhiyong Zhang, Xin Pan, Yue-Yin Pan, Ping Gao, Huafeng Zhang, Cong-Zhao Zhou, Jing Guo*, Zhenye Yang*. Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect. Nature Communications. 2019, 101:5566.

4.   Dongdong Yang#, Linchong Sun, Zhaoyong Li, Ping Gao*. Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming. Advances in Experimental Medicine and Biology. 2016, 927:191-215.

5.   Xiaoyu Ma#, Lin Wang#, De Huang#, Yunyan Li#, Dongdong Yang, Tingting Li, Fudong Li, Linchong Sun, Haoran Wei, Kun He, Fazhi Yu, Debiao Zhao, Lan Hu, Songge Xing, Zhaoji Liu, Kui Li, Jing Guo, Zhenye Yang, Xin Pan, Ailing Li, Yunyu Shi, Junfeng Wang*, Ping Gao*, Huafeng Zhang*. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway. Nature Communications. 2017, 81:1506.

6.   Shi-Ting Li#, De Huang#, Shengqi Shen, Yongping Cai, Songge Xing, Gongwei Wu, Zetan Jiang, Yijie Hao, Mengqiu Yuan, Nana Wang, Lianbang Zhu, Ronghui Yan, Dongdong Yang, Lin Wang, Zhaoji Liu, Xin Hu, Rongbin Zhou, Kun Qu, Ailing Li, Xiaotao Duan*, Huafeng Zhang*and Ping Gao*. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism. 2020, 23:256-269.

7.   Gongwei Wu#*, Caixia Suo#, Ying Yang, Shengqi Shen, Linchong Sun, Shi-Ting Li, Yingli Zhou, Dongdong Yang, Yan Wang, Yongping Cai, Nana Wang, Huafeng Zhang, Yun-Gui Yang*, Jie Cao*, Ping Gao*. MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation. EMBO Reports. 2021 Mar 3;223:e51519.

8.   Shengya Tian#, Junru Feng#, Yang Cao, Shengqi Shen, Yongping Cai, Dongdong Yang, Ronghui Yan, Lihua Wang, Huafeng Zhang, Xiuying Zhong*, Ping Gao*. Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications. Life Science Alliance. 2019, 25:e201900413.